Drug discovery is often romanticized as a moment of serendipity—Alexander Fleming spotting mold on a petri dish. In reality, serendipity is rare. The vast majority of drugs are the result of systematic, rigorous pharmacological interrogation.
Pharmacology determines how a drug enters the bloodstream. Is it orally bioavailable? Does it survive stomach acid? Do gut transporters like P-glycoprotein pump it back into the lumen? Modern drug discovery uses high-throughput Caco-2 cell assays (mimicking human intestinal epithelium) to predict absorption before animal studies. pharmacology in drug discovery and development
Pharmacologists use molecular modeling and in vitro assays to ensure a target is "druggable" and relevant to the disease state. Drug discovery is often romanticized as a moment
Drug discovery is often romanticized as a moment of serendipity—Alexander Fleming spotting mold on a petri dish. In reality, serendipity is rare. The vast majority of drugs are the result of systematic, rigorous pharmacological interrogation.
Pharmacology determines how a drug enters the bloodstream. Is it orally bioavailable? Does it survive stomach acid? Do gut transporters like P-glycoprotein pump it back into the lumen? Modern drug discovery uses high-throughput Caco-2 cell assays (mimicking human intestinal epithelium) to predict absorption before animal studies.
Pharmacologists use molecular modeling and in vitro assays to ensure a target is "druggable" and relevant to the disease state.
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