Matsuzaka's journey in the entertainment industry began at a young age. She started her career as a model, appearing in various Japanese fashion magazines and television commercials. Her big break came in 2006 when she landed a role in the Japanese television drama "Happy 7," followed by a supporting role in the popular drama "Galactic Railways."

Off-screen, Minami Matsuzaka is a reluctant fashion icon. She is frequently photographed arriving at premieres in deconstructed Comme des Garçons suits or vintage Yohji Yamamoto. Unlike the "kawaii" aesthetic pushed by many management agencies, Matsuzaka prefers androgynous looks and natural makeup.