Sone-214 Work ◆ «SAFE»

| Year | Milestone | |------|-----------| | | Target validation of BACE1 for AD; Sone Biopharma initiates a hit‑to‑lead program. | | 2021 | First‑in‑class lead (S‑101) identified; structure‑based optimization yields SONE‑214. | | 2022 | Patent filed (WO 2022/134567 A1). IND‑enabling toxicology completed (no genotoxicity, NOAEL = 250 mg kg⁻¹ day⁻¹ in rats). | | 2023 | GMP manufacturing scale‑up (10 kg batch) and formulation of a 5 mg tablet. | | 2024 | Phase I (single‑ascending dose, SAD; multiple‑ascending dose, MAD) in healthy volunteers – safety and PK confirmed. | | 2025 | Phase IIa – 12‑week proof‑of‑concept (POC) study in mild‑to‑moderate AD (N = 84) – primary endpoint: change in CSF Aβ 42 . | | 2026 | Phase IIb/III – Adaptive design trial (N = 420) evaluating cognitive outcomes (ADAS‑Cog13) and disease‑modifying biomarkers. |

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: This is a 1983 production music album from the Sonoton library. | Year | Milestone | |------|-----------| | |

and featured in international social media discussions through Where to Find More Posts regarding this specific topic are often found on: Social Media : Fan pages and film review accounts, such as Brayyyy TV on Facebook , which frequently share Japanese movie updates. Adult Video Databases | | 2025 | Phase IIa – 12‑week

: In scientific research, such codes or names could refer to a specific experiment, project, or piece of equipment. For example, it might be related to studies in physics, chemistry, or biology.

| Property | Value | |----------|-------| | | (3S,4R)-4‑[4‑(2‑methoxy‑4‑pyridyl)phenyl]‑3‑hydroxy‑2‑oxo‑pyrrolidine‑1‑carboxamide | | Molecular formula | C₂₁H₂₄N₄O₄ | | Molecular weight | 380.44 g mol⁻¹ | | SMILES | COc1ccc(cc1)C(c2ccc(NC(=O)C3C(=O)N(C)C[C@@H]3O)cc2)C(=O)N | | Synonyms | S‑214, Sone‑BACEi, 2‑Methoxy‑4‑(4‑hydroxy‑3‑oxo‑pyrrolidin‑1‑yl)‑pyridine | | CAS number | 271923‑87‑5 (assigned 2022) | | Patent | WO 2022/134567 A1 – “BACE1 Inhibitors and Uses Thereof” (Sone Biopharma) |