In 80% of cases, your antivirus software has eaten the file. Here is how to get it back.
To prevent it from happening again, add the Far Cry 4 installation folder to your list under "Virus & threat protection settings". Method 2: Verify Game Files how to fix far cry 4 uplay-r1-loader64.dll missing
The Uplay/R1 overlay is a notorious source of DLL conflicts. Disabling it forces the game to bypass the faulty loader. In 80% of cases, your antivirus software has eaten the file
Technical Overview: Resolving the "uplay_r1_loader64.dll" Error uplay_r1_loader64.dll In 80% of cases